A Study of the Safety, Tolerability, Pharmacokinetics, and Bioavailability of IV and SC MABT5102A in Healthy Volunteers

Inclusion Criteria * Male subjects aged 18-50 years and female subjects aged 18-50 years who are not of childbearing potential and who are in good general health at the screening visit * Body weight between 50 and 100 kg * For male subjects of reproductive potential, a reliable means of contraception must be used (e.g., abstinence or a condom) for the duration of the study Exclusion Criteria * Female subjects with reproductive potential. * Subjects with evidence of clinically significant neurologic, psychiatric, hepatic, renal, hematologic, pulmonary, respiratory, immunologic system abnormalities, acute infection, or other unstable medical disease * Subjects with any malignancy (with the exception of completely excised basal cell or squamous cell carcinoma of the skin) * History of alcohol, drug, or substance abuse within 6 months prior to randomization that, in the judgment of the investigator, may put the subject at risk for being unable to participate fully in the study for the duration of the study * Past history of seizures, with the exception of childhood febrile seizures * Clinically significant laboratory or ECG abnormalities * Hospitalization during the 4 weeks prior to screening