Weight-reduction Intervention in Asthmatic Children With Overweight/Obesity

Maastricht University Medical Center87 enrolled

Overview

The purpose of this study is to determine the efficacy of a multifactorial intervention with weight reduction, behavioural therapy, and physical exercise on the severity and control of asthma in obese children.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Asthma Overweight Obesity

Interventions

Multifaceted interventionBEHAVIORAL

multifaceted family-based, physical exercise, nutrition, and behavioural intervention study for 18 month, in children aged 6-16 years with asthma and overweight/obesity.

Eligibility

Sex: ALLMin age: 6 YearsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children aged 6-16 years * BMI in the overweight/obesity range according to data of Cole et al. * Asthma diagnosis Exclusion Criteria: * Children with a normal weight according to data of Cole et al. * Children without any provable asthmatic complaints * Congenital malformations of the airways or other chronic lung diseases like cystic fibrosis (CF) * Mental retardation or syndromes * Heart disease

Locations (2)

Maastricht University Medical Centre

Maastricht, Limburg, Netherlands

Maastricht University Medical Centre

Maastricht, Limburg, Netherlands

Outcomes

Primary Outcomes

Forced Expiratory Volume in the first second (FEV1 %) predicted value

Time frame: 2 years

Secondary Outcomes

Airway inflammation

Time frame: 2 years

Symptom-free days, exacerbations

Time frame: 2 years

Need for beta-2 agonists/anti-inflammatory medication

Time frame: 2 years

Weight, height, body mass index (BMI)

Time frame: 2 years

Levels of serum adipokines

Time frame: 2 years

aerobic capacity

VO2max measured with an maximal ergometry test

Time frame: 2 years

Data from ClinicalTrials.gov

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