The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.
The impact of modified ultrafiltration following extracorporeal circulation on primary and secondary hemostasis is controversial. In this study we intend to assess both, primary and secondary hemostasis prior to and after the usage of modified ultrafiltration. Primary hemostasis is assessed using Multiple Electrode Aggregometry (Multiplate) and secondary hemostasis is assessed performing thrombelastometry using the ROTEM device. Patients are preoperatively randomized to receive either modified ultrafiltration or no filtration.
Study Type
OBSERVATIONAL
Enrollment
60
usage of modified ultrafiltration following extracorporeal circulation; filtration about 1,5 liters and re-fill with colloids
Goethe University hospital, Clinic for Anaesthesioloy
Frankfurt am Main, Germany
ex vivo platelet aggregation (TRAPtest)
Time frame: 20 min after filtration
secondary hemostasis assessed by ROTEM
Time frame: 20 min before and after filtration
blood loss
Time frame: 24 h after filtration
kind and number of transfused blood products
Time frame: 24h after filtration
conventional coagulation analyses (INR, aPTT, platelet count, fibrinogen concentration)
Time frame: 20 min before and after filtration
rate of rethoracotomy for bleeding
Time frame: 24h after filtration
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