Glucose-dependent Insulinotropic Polypeptide (GIP) and Lipid Metabolism

Hvidovre University Hospital30 enrolled

Overview

The aim of this proposal is to examine whether endogenous GIP and exogenous GIP alone and in combination with insulin affect gastric emptying (GE), appetite, energy intake, energy expenditure (EE) and plasma levels of triglycerides (TAG), free fatty acids FFA) and glycerol in man.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy Subjects

Interventions

Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)OTHER

two different dosages: * 0.8 pmol/kg/min * 1.5 pmol/kg/min for 300 minutes

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Informed oral and written consent * Caucasians over the age of 18 years * Normal 75 g oral glucose tolerance test (OGTT) * Normal blood haemoglobin concentration * Normal plasma lipid profile Exclusion Criteria: * First-degree relatives with diabetes and familial hypertriglyceridemia

Locations (1)

Hvidovre Hospital

Hvidovre, Denmark

Data from ClinicalTrials.gov

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