Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT

King's College London10 enrolled

Overview

The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile. It is important to determine which patients are most at risk so that surgery can be performed. There is evidence that the risk is greatest when these plaques become oxygen deficient (hypoxic). The investigators wish to use PET imaging to identify hypoxic plaque, to help decide whether and when to perform surgery. The investigators have developed radiotracers (imaging agents) for this purpose, and this study is to determine whether they will work in patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Carotid Atherosclerosis

Interventions

PET-CT with CuATSMOTHER

PET-CT with CuATSM

Eligibility

Sex: ALLMin age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male/Female patients who are 55yrs or older and for whom carotid endarterectomy is clinically indicated and a decision has been made to perform a carotid endarterectomy. * Normal liver and adequate renal function. Assessed by measuring eGFR (\>50ml/min) and creatinine (\<130μmol/L) * Life expectancy \> 12 weeks * Patients should be able to tolerate head/neck mask as well as lying in the PET-CT scanner Exclusion Criteria: * Abnormal liver and renal function (eGFR \<50ml/min, Creatinine \>130μmol/L) * Patient unwilling to provide written informed consent

Locations (1)

St Thomas' Hospital

London, United Kingdom

Outcomes

Primary Outcomes

Uptake of CuATSM in carotid plaque

Time frame: Within 30 days of carotid endarterectomy

Secondary Outcomes

Relationship of CuATSM uptake to plaque histology

Time frame: Within 30 days of carotid endarterectomy

Data from ClinicalTrials.gov

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