An open-label, 3-period, fixed-sequence study in a panel of 18 HIV-infected patients on MK0518 as part of a stable treatment regimen for HIV.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
18
400 mg oral tablet of MK0518 once every 12 hours. Period 1 duration is one day, Period 2 duration is one day, Period 3 duration is five days.
Single 20 mg famotidine oral tablet taken 2 hours prior to administration of AM dose of MK0518
20 mg oral tablet of omeprazole, once daily for 5 days
Plasma Area Under Curve (AUC 0-12 hr ) for Raltegravir
Area Under the Plasma Concentration-Time Curve and peak concentration
Time frame: 12 hours postdose
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