A Study of PRT-201 Administered After Arteriovenous Graft (AVG) Creation in Patients With Chronic Kidney Disease

Inclusion Criteria: 1. Age of at least 18 years. 2. Chronic kidney disease with anticipated start of hemodialysis within 3 months or current hemodialysis dependence. 3. Planned creation of a new upper extremity AVG or "jump" graft Exclusion Criteria: 1. Patients for whom this is the only potential site for an upper extremity vascular access. 2. Creation of a new AVG or "jump" graft in an upper extremity previously treated with an investigational gene or cell based therapy, or locally with an investigational pharmacological agent. 3. On physical examination or by other means, suspected proximal vein stenosis, occlusion, lack of continuity with the subclavian vein, central venous stenosis or central venous occlusion. 4. History or presence of an arterial aneurysm. 5. Previous treatment with PRT-201.