Assess the Ability of Electrical Cardiometry to Trend Hemodynamic Variables During Dexmedetomidine Sedation

Boston Children's Hospital17 enrolled

Overview

The aim of the study is to investigate the use of a new FDA-approved non-invasive bio-impedance cardiac monitor, ICON, to detect hemodynamic effects during sedation in children undergoing radiology procedures. The purpose of the study is to determine the ability of the ICON monitor to identify the anticipated and documented hemodynamic changes in children which occur in response to Dexmedetomidine sedation. The investigators postulate that if the ICON device can trend hemodynamic changes, if any, during dexmedetomidine (DEX) sedation in children the investigators can delineate changes in cardiac output, stroke volume, and systemic vascular resistance associated with observed changes in heart rate and blood pressure.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Output Sedation

Eligibility

Sex: ALLMin age: 1 MonthMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All pediatric patients (1 month to 18 years of age) * Eligible for Radiology Sedation Service for CT scan and Nuclear Medicine * Scan procedure Exclusion Criteria: * Pacemakers and Vagus Nerve Stimulator * Mitral or Aorta Valve Dysfunction * Dextrocardia * Second or Third degree heart block * Current diagnosis of Cardiac, Pulmonary, Hepatic or Renal Failure * Current diagnosis of pulmonary masses/tumor/pleural effusions/pneumonia/edema * Pericardial effusion * Concomitant use of hypertension medications including ACE inhibitors, beta receptor and calcium channel blockers. * Large Implanted Metallic Devices (including orthodontic braces, spine rods, plates and screws) * Allergy to device electrodes

Outcomes

Primary Outcomes

The primary aim is to ascertain if a decrease in heart rate (HR) with intravenous (IV) DEX is associated with a change in trend of cardiac output (CO) as measured by the ICON device.

Time frame: pre-, during, and post sedation

Secondary Outcomes

To determine the cardiac parameters provided by the ICON device during changes in blood pressure.

Time frame: pre-, during and post sedation