A Study of Endostar Combined With Chemotherapy for Treatment of Osteosarcoma

Inclusion Criteria: * Patients with histologically confirmed osteosarcoma, who have no evidence of metastasis * At least one measurable lesion * Life expectancy \> 3 months * ECOG performance status 0-2 * Adequate hematologic, cardiac, renal, and hepatic function * Patients with prior chemotherapy should have at least 4 weeks clearance period before entering this study Exclusion Criteria: * Evidence of metastasis * Serious infection * Evidence of bleeding diathesis * Significant cardiovascular disease * Pregnant or lactating woman * Allergic to E.coli preparation