Micronutrient Supplementation in Patients With Heart Failure

Belfast Health and Social Care Trust79 enrolled

Overview

There is some evidence to suggest that patients with heart failure may have a reduced dietary intake of vitamins and essential minerals (micronutrients) and that this may worsen the function of the heart. This study is designed to investigate if supplementation with micronutrients (including high-dose vitamin D) will improve the function of the heart in patients with heart failure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Heart Failure

Interventions

PlaceboDRUG

1 Tablet Daily

Forceval plus 50 micrograms Vitamin D3DRUG

Forceval: 1 Tablet Daily; Vitamin D3: 2 Tablets Daily

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * New York Heart Association Class II and III * Already on or tried on best known medical treatment (ACE inhibitor and beta-blocker) * Stable for a period of at least 6 weeks * Left ventricular ejection fraction less than or equal to 45% Exclusion Criteria: * History of significant alcohol ingestion (more than 40 units per week) * Severe renal dysfunction (GFR less than 30ml/min) * Severe hepatic dysfunction (known liver disease or transaminases greater than 3 times the upper limit of normal) * Atrial fibrillation (in the absence of a pacemaker) * Frequent ventricular ectopics * On waiting list for cardiac transplantation * Uncontrolled diabetes mellitus * Inability to give informed consent * Estimated life span less than 12 months * Already taking a multivitamin/mineral supplement * Already taking a vitamin-D containing fish oil * Woman of child-bearing potential * History of renal stones, hypercalcaemia, sarcoidosis, haemochromatosis or lactose intolerance

Locations (1)

Royal Victoria Hospital

Belfast, United Kingdom