Effects of Dietary Protein Intake From Beef/Pork and Soy/Legumes on Appetite, Mood, and Weight Loss

Purdue University37 enrolled

Overview

The primary aims of this study are to assess the effects of habitual dietary protein intakes across the acceptable macronutrient distribution range with lean beef/pork or soy/legumes as the predominate sources of protein on indices of daily appetite and mood, and on postprandial appetite, mood, energy expenditure, and glycemic responses during energy-restricted weight loss in overweight adults.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Appetite Mood Weight Loss

Interventions

Beef/PorkOTHER

Participants consuming diet containing 10, 20 or 30% dietary protein with beef/pork as the predominate sources of protein

Soy/LegumesOTHER

Participants consuming diet containing 10, 20, or 30% dietary protein with soy/legumes as the predominate sources of protein.

Eligibility

Sex: ALLMin age: 21 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age range: 21 years and older * Body mass index between 27.0-36.9 kg/m2 * Non-smoking (within the last 6 months) * Weight stable (\< 3 kg (\~7 lbs) weight gain or loss within last 3 months) * Energy need for weight maintenance 1950-2750 kcal/day * Not dietary restrained * Menstruating women not pregnant or lactating * Constant habitual activity patterns (within last 3 months) * No Acute Illness (or have chronic diseases known to influence protein or energy metabolism) * Non-diabetic * Clinically normal blood profiles (within 10% of clinical normalcy) * Non-hypertensive * Not taking medications known to influence appetite or metabolism * Willingness to eat study foods * Able to travel to testing facility Exclusion Criteria: * Age: \<21 years * Body mass index: outside of the 27.0-36.9 kg/m2 range * Smoker (currently or within the last 6 months) * Gained or lost \> 3.0 kg (7 lbs) within the last 3 months * Energy need for weight maintenance \< 1950 or \> 2750 kcal/day * Dietary restrained (≥ 14 on Three Factor Eating Questionnaire) * Pregnant, lactating, or non-menstruating women * Clinically diagnosed as a diabetic, or with liver or kidney disease/dysfunction, or osteoporosis * Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD * Hypertensive * Taking medications (currently or within the last 3 months) known to influence appetite or metabolism * Allergies to eggs * Lactose intolerance * Unwillingness to eat study foods * Inability to travel to testing facility

Locations (2)

Purdue University

West Lafayette, Indiana, United States

Purdue University

West Lafayette, Indiana, United States

Outcomes

Primary Outcomes

Increasing protein intake from lean beef/pork or soy/legumes sources will result in progressively decreased daily composite hunger and desire to eat, and increased fullness. The responses will not be different between groups of subjects.

Time frame: 14 weeks

Secondary Outcomes

Increasing the protein content of a test will result in progressively more robust and sustained changes in postprandial appetite and energy expenditure and blunted glycemic response. The responses will not be different between the groups of participants.

Time frame: 14 weeks

Data from ClinicalTrials.gov

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