Effect of PF-04360365 On ABETA In Patients With Alzheimer's Disease And Healthy Volunteers

Inclusion Criteria: * Males or females of non-childbearing potential (age 50 and over for Alzheimer's disease patients; 21-45 for healthy volunteers) * For patients with Alzheimer's Disease: Diagnosis of probable Alzheimer's disease, consistent with criteria from both National Institute of Neurological and Communicable Disease and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and Diagnostic and Statistical Manual of Mental Disorders (DSM IV) * Mini-mental status exam score greater than or equal to 20 * Rosen-Modified Hachinski Ischemia Score of \< or = 4 * On stable dose of background cholinesterase inhibitor or memantine at least 3 months prior to enrollment Exclusion Criteria: * Diagnosis or history of other demential or neurodegenerative disorders * Diagnosis or history of clinically significant cerebrovascular disease * Specific findings on magnetic resonance imaging (MRI); cortical infarct, micro hemorrhage, multiple white matter lacunes, extensive white matter abnormalities * History of autoimmune disorders * History of allergic or anaphylactic reactions