Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables

Purdue University55 enrolled

Overview

The purpose of this research study is to determine how dietary fats and oils influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine changes in blood carotenoids in response to eating a salad with different fats/oils.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Absorption of Carotenoids From Vegetables

Interventions

Soybean OilOTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.

Canola OilOTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.

ButterOTHER

Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age range: 18-50 years. * Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m² * Weight stable (\<4.5 kg change within the last 3 months), * Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months. * Must be pre-menopausal * Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl) * Non-smoking * Non-diabetic * No current or planned pregnancy * Not using any hormone-based contraceptive, e.g., pill, patch, injection, implants, etc. * No current use of medication affecting lipid profile * No intestinal disorders including lipid malabsorption, lactose intolerance * No heavy consumption of alcohol (\>2 drinks per day) * No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study. Exclusion Criteria: * Menopausal * Diabetic * Currently pregnant * Currently using any type of hormone-based contraceptives, (e.g., pill, patch, injection, implants, etc.) * Use of lipid altering medications

Locations (1)

Purdue University

West Lafayette, Indiana, United States

Outcomes

Primary Outcomes

Evaluating the impact of dietary lipid profiles on intestinal absorption of carotenoids from vegetables.

Time frame: 66 days

Data from ClinicalTrials.gov

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