Antibacterial Properties of Silicon Incorporated With Quaternary Ammonium Polyethylenimine Nanoparticles

Hadassah Medical Organization10 enrolled

Overview

The aim of this study is to evaluate the antibacterial activity of crosslinked quaternary ammonium polyethylenimine (PEI) nanoparticles incorporated at 1-2% w/w in a commercial soft liner material when compared to the commercial soft liner material. The investigators' results in vitro showed a significant delay in bacterial growth. Therefore, the investigators assume to have the same delay in vivo- on patients.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Carcinoma of Head and Neck

Interventions

polyethylenimine (PEI) nanoparticles.DEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients post maxillectomy, who are using obturators Exclusion Criteria: * patients who are not using obturators

Outcomes

Primary Outcomes

bacterial growth

Time frame: a week

Central Contacts

anat b sharon, Msc, DMD

CONTACT

972-54-5255659 anatsharon@hadassah.org.il

Data from ClinicalTrials.gov

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