Effect of Dexamethasone Combined With Ondansetron on Postoperative Nausea and Vomiting in Patients With Patient-controlled Analgesia After Video-assisted Thoracoscopic Surgery

Yonsei University123 enrolled

Overview

The purpose of this study is to study the effect of dexamethasone combined with ondansetron on postoperative nausea and vomiting in patients with patient-controlled analgesia after video-assisted thoracoscopic surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

123

Conditions

Nausea Vomiting

Interventions

DexamethasoneDRUG

Experimental: Dexamethasone 8 mg IV after induction of anesthesia, Ondansetron 4 mg IV at the end of surgery and 12 mg mix to intravenous patient controlled analgesia device.

OndansetronDRUG

Active comparator: Ondansetron 4 mg IV at the end of surgery and 12 mg mix to intravenous patient controlled analgesia device.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing video-assisted thoracoscopic surgery * Age 20-75 * American Society of Anesthesiologists physical status classification I or II Exclusion Criteria: * Antiemetic within 24 hrs * Taking Steroids, Opioids within 1 week * Active drug or alcohol abuse * GI motility disorder, severe renal/ hepatic disease.

Locations (1)

Severance Hospital, Yonsei University College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

Incidence of postoperative nausea and vomiting

Time frame: within 48 hrs after surgery

Data from ClinicalTrials.gov

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