Efficacy and Safety of CDP-choline in Patients With Methamphetamine Dependence

Inclusion Criteria: * 19-60 year-old male or female * Methamphetamine dependence diagnosed by DSM-IV * Total cumulative dose for methamphetamine during the last two years: over 10 gram (over 200 shots of 0,05 mgram intravenous methamphetamine injection) * Methamphetamine use in recent 4 weeks * Subscale score of drug use in ASI: \>2 Exclusion Criteria: * Significant current or past medical, neurological, or psychiatric co-morbidity including cardiovascular, renal, and endocrine disorder, as identified by medical history * Lifetime axis I psychiatric disorders of bipolar disorder, schizophrenia, identified by SCID-IV * Socially dysfunctional antisocial personality disorder * Current alcohol or nicotine dependence identified by SCID-IV * Taking psychotropic medication in recent two months * Head trauma history with loss of consciousness or seizure * Intelligence quotient \< 80 * Pregnant subjects. In addition, women of childbearing potential who will not practice a medically accepted method of contraception will be excluded. Female subjects who are of child-bearing potential will have to pass a urine pregnancy test before each visit. * Any contraindication to an MR scan