Dose-dependent Effects of Second-hand Smoke on Vascular Function

University of California, San Francisco33 enrolled

Overview

The purpose of this study is to determine the vascular effects of brief second-hand smoke exposure on normal healthy individuals.

Second-hand smoke remains a significant public health threat. Despite evidence to suggest that secondhand smoke contributes to adverse cardiovascular outcomes, little is known about the dose-dependent vascular effects of brief secondhand smoke exposure at low doses commonly encountered in the community. This study will investigate the acute vascular effects and dose-dependent biological mechanisms of secondhand smoke on endothelial function and oxidative stress.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Cardiovascular Disease

Interventions

Respirable suspended particles (RSP) PM 2.5 dose of second-hand smokeOTHER

acute one time exposure

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy non-smoking adults Exclusion Criteria: * Reported Active Smoking * History of diabetes, hypertension, chronic respiratory disease, coronary artery disease, prior myocardial infarction or heart failure * Pregnancy or breastfeeding * Current use of prescription drugs within 14 days of trial * Reported significant passive smoke exposure or elevated cotinine levels

Locations (1)

UCSF San Francisco General Hospital

San Francisco, California, United States

Outcomes

Primary Outcomes

Brachial Artery Flow-mediated dilation (FMD)

Time frame: Same day - before/after exposure

Secondary Outcomes

Plasma measurement of asymmetric dimethylarginine (ADMA) and Nitrotyrosine levels

Time frame: Same day - before/after exposure

Data from ClinicalTrials.gov

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