GnRH agonist administration in the luteal phase was reported to beneficially affect clinical outcome of ICSI-ET cycles. This randomized controlled trial evaluates the effect of a single dose GnRH agonist administered in the luteal phase on the outcome of ICSI - ET cycles stimulated with the fixed GnRH antagonist protocol. Women undergoing embryo transfer following controlled ovarian hyperstimulation with a fixed GnRH antagonist protocol were included. In addition to routine luteal phase support with progesterone women were randomized to receive a single dose of GnRH agonist or placebo on the sixth day after ICSI.Ongoing pregnancy rate was the primary outcome measure.
Study Type
INTERVENTIONAL
single dose of 0.1 mg triptorelin subcutaneous injection on the 3rd day after embryo transfer
0.1 ml sterile saline sc injection 3 days after embryo transfer
American Hospital
Istanbul, Turkey (Türkiye)
Ongoing pregnancy beyond 20th gestational week
clinical pregnancy rate
Embryo implantation rate
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