Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis

Uppsala University600 enrolled

Overview

The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis. The hypothesis is that Patients with acute uncomplicated colonic diverticulitis will recover the condition without antibiotic therapy and the lack of antibiotic therapy will not lead to complications. The patients will be randomized to conservative treatment with and without antibiotic therapy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

600

Conditions

Colonic Diverticulitis

Interventions

AntibioticDRUG

Antibiotic according to local treatment routine against bowel pathogenesis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adults with CT sign of acute colonic uncomplicated diverticulitis * elevated CRP and LPK * Temp.38c or more Exclusion Criteria: * patients with peritonitis, sepsis or CT- sign of complicated diverticulitis with abscesses or free abdominal air * pregnancy * immunological incompetence and immunosuppressive therapy

Locations (1)

The Central Hospital

Västerås, Västmanland County, Sweden

Outcomes

Primary Outcomes

discharge without complications +/- antibiotic therapy

Time frame: Within 30 days after discharge

Secondary Outcomes

to evaluate length of hospital stay, cost and late complications

Time frame: one year after admission

Data from ClinicalTrials.gov

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