The pharmacokinetics of sodium thiosulfate in humans with different degrees of renal failure and in healthy volunteers will be after two single shot applications.
Two single shot applications of i.v. sodium thiosulfate will be given to dialysis patients. One application will be given immediately before a dialysis session and the second dose will be given after the consecutive dialysis session. In healthy volunteers sodium thiosulfate will be given only once. In both groups, dialysis patients and healthy volunteers, blood and urinary/dialysate samples will be collected at defined time points.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
19
6g of Sodium Thiosulfate are applicated in a short infusion over a time of 5 min
Department of Nephrology and Hypertension, University of Berne
Bern, Canton of Bern, Switzerland
Elimination half life in dependence of the degree of renal failure
Time frame: 0, 15, 30, 60, 180 minutes and 24 hours after application
Changes in acid-base parameter after application of sodium thiosulfate
Time frame: 0, 15, 30, 60, 180 minutes and 24 hours after application
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