Multipolar Radiofrequency Ablation for Hepatocellular Carcinoma Using Extra Nodular Versus Intranodular Technique

Inclusion Criteria: * Adults \> 18 years old, holder of up to 3 nodules less than 4 cm in diameter * Diagnosis of hepatocellular carcinoma according to American Society of Liver Study non invasive criteria or based on histological proof * Non invasive diagnosis of cirrhosis according to French Haute Authority of illness guideline or based on histological proof * No previous treatment for hepatocellular carcinoma * Multidisciplinary decision of treatment by radiofrequency ablation Exclusion Criteria: * Adult patient under guardianship or trusteeship, homeless * Patient with potentially short term life-threatening serious co-infection (apart from viral B or C, or VIH co-infection) * Pregnant or breastfeeding woman * Patient for whom regular follow-up is impossible whatever the cause * Contra indication to general anaesthesia * Technical impossibility to perform the procedure under ultrasound guidance * Boundary of the tumor located at less than 1 cm distance from colonic wall or main biliary tract (main right or left bill ducts and common bill duct) * Tumor invisible with ultrasound * Lack of safe percutaneous course which can be planned * Tumor in which more than four biopsies pass were previously performed (cumulated during one or several previous biopsies sessions) * Contra indication to perform CT or MRI with contrast medium (GADOLINITE or iodinate) intravenous injection * Child-Pugh B or C cirrhosis (apart from the transitory liver failures in the setting of acute hepatitis related to alcohol abuse) * Total detachment of the anterior face of the liver from internal abdominal wall due to abundant ascites. * Prothrombin activity \< 50 % * Platelet count \<40 .10 3/ml * Platelet dysfunction or congenital impaired blood coagulating