A Study of ABT-384 Levels and Pharmacodynamic Activity Measured in Cerebrospinal Fluid

Inclusion Criteria: * Age is between 18 and 55 years * Judged to be in a condition of general good health based on the results of medical history, physical examination, vital signs, laboratory profile and a 12-lead ECG Exclusion Criteria: * Use of protocol-prohibited medications within 2 weeks prior to study drug administration. * Positive urine drug screen for non-prescribed drugs of abuse including alcohol. * Receipt of any drug depot by injection within 30 days prior to study drug administration. * Receipt of any investigational product within 6 weeks prior to study drug administration. * History of significant sensitivity or allergy to any drug. * History of drug or alcohol abuse. * Positive test result for HAV, HBsAg, HCV or HIV. * Donation or loss of 550 mL or more blood volume or receipt of any blood product within 3 months prior to study drug administration. * Contraindication for lumbar puncture (e.g., lumbar scoliosis, coagulopathy, infected skin at puncture site) * Current enrollment in another clinical study.