A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?

Insel Gruppe AG, University Hospital Bern100 enrolled

Overview

Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation according to official guidelines. An assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.

Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation. The assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Renal Failure Renal Transplantation Living Donors

Interventions

Low and high salt dietsDIETARY_SUPPLEMENT

High salt diet: 150mmol/d Low salt diet: 30mmol/d

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acceptance for living kidney donation Exclusion Criteria: * withdrawal of consent

Locations (1)

Department of nephrology and hypertension, Universitiy of Bern

Bern, Canton of Bern, Switzerland

Outcomes

Primary Outcomes

Salt sensitivity, arterial hypertension

Time frame: day 0, 14, 52, 156, 208, yearly

Data from ClinicalTrials.gov

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