A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.
Study Type
OBSERVATIONAL
Enrollment
50
Stanford University School of Medicine
Stanford, California, United States
Anesthetic Recovery Times
recovery from anesthesia will be measured by short-term outcomes like time to tracheal extubation and response to verbal commands, as well as by psycho-vigilance testing up to 72 hours postoperatively
Time frame: 0-72 hours after surgery
sensitivity to sevoflurane during inhalation induction to anesthesia, determined by bispectral index of the EEG
pharmacodynamic analysis of bispectral index of the EEG response to sevoflurane
Time frame: during anesthetic induction
pain and sleepiness
assessment of pain and sleepiness using the numerical rating scale (0-10) during the 72 hours postoperatively
Time frame: from 0-72 hours after surgery
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