Everolimus on CKD Progression in ADPKD Patients

Inclusion Criteria: 1. Subjects over 18 years of both genders 2. Clinical diagnosis of autosomal dominant polycystic kidney disease (ADPKD) 3. GFR, according to MDRD formula, between 30 and 90 ml/min/1.73 mq 4. Previous follow up of two years, with a creatinine evaluation at least once a year 5. GFR reduction of at least 2.5 ml/min/year (according to MDRD formula) Exclusion Criteria: 1. Pregnancy, lactating, males and females without adequate contraception 2. Leucopenia (\< 3,000 leucocytes/mm3) or thrombocytopenia (\< 100,000 platelets/mm3) 3. Dyslipidemia (cholesterol or triglycerides \> 260 mg/dl with treatment) 4. Urinary tract infection 5. Patients who cannot undergoing NMR