Safety and Efficacy Study of Autologous Cultured Adipose -Derived Stem Cells for the Crohn's Fistula

Inclusion Criteria: * Older than 18 years * Prior diagnosis of Crohn's disease * patients who have Crohn's fistula * negative for serum beta-HCG for woman of childbearing age * agreement to participate, with signed informed-consent Exclusion Criteria: * patients who have allergy to bovine-derived materials or an anesthetic * patients with a diagnosis of auto immune disease except for Crohn's disease * Diagnosis of HBV, HCV, HIV and other infectious disease * Patients who have a symptom of septicemia * Patients with a diagnosis of active Tuberculosis * Patient who are pregnant or breast-feeding * Patients who are unwilling to use an "effective" method of contraception during the study * Patients with a diagnosis of Inflammatory Bowel Disease except for Crohn's disease * Patients who are sensitive to Fibrin glue * Patients who have a clinically relevant history of abuse of alcohol or drugs, habitual smoker * Insufficient adipose tissue for manufacturing of ADIPOPLUS * Patients who are considered not suitable for the study by investigator * Patients with a diagnosis of active refractory Crohn's disease * Patients who have history of surgery for malignant cancer in the past 5 years * Patients who have \> 2 cm diameter of fistula