Dose Escalation Study of MLN4924 in Adults With Melanoma

Inclusion Criteria: Each patient must meet all of the following criteria to be enrolled in the study: * Diagnosis of metastatic melanoma * Measurable disease * Female patients who are post menopausal, surgically sterile, or agree to practice 2 effective methods of contraception or abstain from heterosexual intercourse * Male patients who agree to practice effective barrier contraception or agree to abstain from heterosexual intercourse * Willing and able to give written informed consent * Suitable venous access for study-required blood sampling * Appropriate functional status, including the recovery from the effects of prior antineoplastic therapy, and acceptable organ function as described in the protocol Exclusion Criteria: Patients meeting any of the following exclusion criteria are not to be enrolled in the study: * Major surgery or, serious infections, or infections that required systematic antibiotic therapy within 14 days before the first dose of study drug * Systemic antineoplastic or radiation therapy within 14 days or treatment with any investigational products within 21 days before the first dose of study treatment * CYP3A inducers within 14 days of study treatment. Moderate and strong CYP3A inhibitors and CYP3A inducers are not permitted during the study * No prior history of amiodarone in the 6 months before the first dose of MLN4924 * Diarrhea that is greater than Grade 1 as outlined in the protocol * Evidence of current uncontrolled cardiovascular conditions, including cardiac arrhythmias, congestive heart failure, angina, or myocardial infarction within the past 6 months * Known human immunodeficiency virus (HIV) positive, hepatitis B surface antigen-positive status, or known or suspected active hepatitis C infection. * Serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to the protocol * Other clinical and laboratory assessments that do not meet the criteria specified in the protocol