Safety Study of Autologous Cultured Adipose -Derived Stem Cells for the Fecal Incontinence

Inclusion Criteria: * Older than 18 years * Wexner's fecal incontinence score \> or egal 5 * patient who has fecal incontinence for more than 6 months * Continuity of anal sphincter at endorectal ultrasound and abnormality of anal function at anorectal manometry * negative for urine beta-HCG for woman of childbearing age * agreement to participate, with signed informed-consent Exclusion Criteria: * Anorectal surgery within the last 6 months prior to the study * patient who is allergy to bovine-derived materials and an anesthetic * patients with a diagnosis of auto immune disease * Diagnosis of HBV, HCV, HIV and other infectious disease * Patients with a diagnosis of active Tuberculosis * Patient is pregnant or breast-feeding * Women within 6 months post partum * Patient who is unwilling to use an "effective" method of contraception during the study * Patients with a diagnosis of Inflammatory Bowel Disease * Patient who has a clinically relevant history of abuse of alcohol or drugs * Insufficient adipose tissue for manufacturing of ANT-SM * Patient whom investigator consider is not suitable in this study * Patients have history of surgery for malignant cancer in the past 5 years * Patient who has to undergo ano-rectal surgery * Patient who has a history of artificial anal sphincter surgery * Patient who has taken cytotoxic drugs within the last 30 days * Patient whom investigator consider is not suitable in this study reasons for severe ano-rectal disease, severe constipation, fistula, rectal prolapsed or neurological diseases (spinal cord injury, multiple sclerosis, Parkinson's disease)