Local Anesthetic in Total Knee Arthroplasty (TKA): Volume Versus Concentration

Lundbeck Foundation48 enrolled

Overview

In a randomized, double-blind, cross-over trial, 48 patients scheduled for total knee arthroplasty with placement of an intracapsular catheter will be randomized to receive bolus injection of ropivacaine in high volume/low concentration (20 ml, 5 mg/mL) or low volume/high concentration (10 mL, 10 mg/mL) 6 and 24 hours postoperatively, and pain will be assessed at rest and with mobilization for 2 hours after injections.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain Analgesic Efficacy

Interventions

20 mL ropivacaine 5 mg/mLDRUG

10 mL ropivacaine 10 mg/mLDRUG

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Scheduled for total knee arthroplasty * Able to give informed oral and written consent to participate Exclusion Criteria: * Treatment with opioids or steroids, rheumatoid arthritis or other immunological diseases * History of stroke or any neurological or psychiatric disease potentially influencing pain perception (e.g. depression, diabetic neuropathy etc.) * Allergies to any of the drugs administered.

Locations (1)

Lundbeck Centre for fast-track hip and knee arthroplasty

Copenhagen, Denmark

Outcomes

Primary Outcomes

postoperative pain

Time frame: 32 hours postoperative

Data from ClinicalTrials.gov

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