Safety and Efficacy of Aprepitant, Ramosetron, and Dexamethasone for Chemotherapy-Induced Nausea and Vomiting in Patients With Ovarian Cancer Treated With Taxane/Carboplatin

Inclusion criteria 1. patient is over 18 years 2. ovarian carcinoma patients who are treated with moderately emetogenic chemotherapy 3. Karnofsky score \> 60 4. Life expectancy \> 4 months Exclusion criteria 1. Any of following conditions (mentally incapacitated or emotional or psychiatric disorder, user of any illicit drugs, has an active infection, hypersensitivity to ramosetron or aprepitant) 2. Patients have received a nonapproved drug within last 4 weeks 3. abnormal laboratory values (AST \> 2.5 normal, ALT \> 2.5 normal, Bilirubin \> 1.5 normal, Creatinine \> 1.5 normal) 4. Antiemetic drugs within 48 hours of study 5. Benzodiazepine or opiate within 48 hours 6. CYP3A4 substrates within 7 days (terfenadine, cisapride, astemizole, pimozide) 7. CYP3A4 inhibitors (clarithromycin, ketoconazole) 8. CYP3A4 inducers within 30 days (Barbiturates, rifampicin, carbamazepine)