Effect of Vitamin D Supplement on Inflammation Markers in High-Risk Cardiovascular Patients With Chronic Kidney Disease

Inclusion Criteria: * Men and non-pregnant, non-lactating women greater than 18 years of age * Able to given informed consent and complete scheduled visits * History of established coronary artery disease (CAD)as defined by coronary stenosis in one or more vessels greater than or equal to 70% by coronary angiography or CT angiogram OR abnormal stress test (at least medium-sized, moderate reversible defect) OR a presence of a CAD risk equivalent as defined by the National Cholesterol Education Panel (NCEP)III as: Framingham risk score ≥ 20%, diabetes, or peripheral arterial disease(4) * High Sensitivity C-reactive Protein (hs-CRP) ≥ 2.0 mg/L * History of stage 3 or 4 chronic Kidney disease (CKD) defined as an glomerular filtration rate (eGRF) by the Modification of Diet in Renal Disease (MDRD) formula of 15-60 mL/min/1.73 m2 * Low level of serum 25-hydroxyvitamin D (\<30ng/mL) * Evidence of secondary hyperparathyroidism defined as intact parathyroid hormone (iPTH) level \> 70 pg/mL * Stable dose of statin and/or other lipid lowering therapy (ie: ezetimibe, fibrates, bile acid sequestrants nicotinic acid, fish oil) for 12 weeks prior to enrollment without known plans for change to current therapy during the study period Exclusion Criteria: * History of myocardial infarction, stroke, or cardiac surgery within 6 months of enrollment * History of carotid artery surgery * Planned cardiovascular surgery or procedure, with the exception of permanent pacemaker placement, in the next 18 months. * Use of vitamin D or calcium supplementation within the past 12 weeks with the exception of calcium containing phosphate binders and a daily multivitamin containing ≤ 400 IU of vitamin D * Hypercalcemia (as defined by the laboratory upper limit of normal ) or hyperphosphatemia (≥ 5.5 mg/dL) * Plan to initiate renal replacement therapy (dialysis) during the study * History of left ventricular systolic dysfunction with an ejection fraction \<50% or history of New York Heart Association (NYHA)functional Class II-IV congestive heart failure * Uncontrolled blood pressure, defined as systolic blood pressure greater than 160 mmHg and diastolic blood pressure greater than 100 mm Hg at the screening visit * Uncontrolled diabetes, defined as hemoglobin A1C ≥ 10.0 * History of any surgery within the past 3 months or known to be planned during the study period * History of malignancy within the past 5 years with the exception of non-melanoma (ie: squamous cell or basal cell) skin cancer * History of a known systemic or pulmonary inflammatory condition (including rheumatoid arthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease, pulmonary fibrosis, sarcoidosis, Wegener's granulomatosis, Goodpasture's disease) * History of renal or other organ transplant and/or immunosuppressed state (ie immunosuppressive therapy or condition such as HIV) * History of any other condition, that in the opinion of the investigators renders it unsafe for the subject to be enrolled * For woman able to become pregnant, unwillingness to use birth control * Participation in another clinical trial