Comparison of a PEG Membrane and a Collagen Membrane for the Treatment of Bone Dehiscence Defects at Bone Level Implants

Inclusion Criteria: * Subjects must have voluntarily signed the informed consent form before any study related action * Males and females must be at least 18 years of age and not more than 80 year old. * Have at least one missing tooth in the posterior mandible or maxilla in quadrant 1, 2, 3, 4 (FDI positions 4-7), requiring one or more dental implants. * Partially edentulous patients and patients in need of a fixed dental prosthesis * The tooth at the implant site(s) must have been extracted or lost at least 6 weeks before the date of implantation. * Bone defect(s) must be present with a vertical dimension greater than or equal to 3 mm at the foreseen GBR site measured after dental implant placement. * Full mouth bleeding on Probing (FMBoP) and full mouth plaque score (FMPI) are both lower or equal than 25% * Patients must be committed to the study. Exclusion Criteria: * Presence of conditions requiring chronic routine prophylactic use of antibiotics (e.g., history of rheumatic heart disease, bacterial endocarditis, cardiac valvular anomalies, prosthetic joint replacements) * Major systemic diseases * Medical conditions requiring prolonged use of steroids * Use of Bisphosphonate intravenously * Current pregnancy or breastfeeding women * Physical or mental handicaps that would interfere with the ability to perform adequate oral hygiene * Alcoholism or chronically drug abuse * Immunocompromised patients * Patients who smoke more than 10 cigarettes per day or cigar equivalents, or who chew tobacco * Conditions or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, or unreliability. Local exclusion criteria * Local inflammation, including untreated periodontitis * Regenerative treatment necessary adjacent to the planned study site of interest * Mucosal diseases or oral lesions * History of local irradiation therapy * Severe bruxing or clenching habits * Persistent intraoral infection * Patients with inadequate oral hygiene or unmotivated for adequate home care * Previous GBR or GTR treatment at the implant site * Lack of primary stability of the dental implant at site of interest. In this instance the patient must be withdrawn and the patient treated accordingly (exclusion criteria at surgery)