Efficacy of Dexamethasone Added to Ramosetron for Preventing Postoperative Nausea and Vomiting in Highly Susceptible Patients Following Spine Surgery

Yonsei University94 enrolled

Overview

The purpose of this study is to study the efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Nausea Vomiting

Interventions

ramosetron with salineDRUG

Group A : saline 1 ml, ramosetron 6μg/kg

ramosetron with dexamethasoneDRUG

Group B : dexamethasone 4 mg, ramosetron 6μg/kg

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Females * Ages 18 to 65 years old Exclusion Criteria: * Patients who is taking steroid or who had been treated for the gastrointestinal disease * Patients who have troubles with the kidney or liver * Patients transferring to the ICU after the surgery * overfat patients * Patients who had taken antiemetics within 24 hours before the surgery

Outcomes

Primary Outcomes

the incidence of postoperative nausea and vomiting(PONV)

incidence of overall postoperative nausea and vomiting (PONV) between combination of ramosetron and dexamethasone and ramosetron alone in highly susceptible patients

Time frame: After spinal surgery

Data from ClinicalTrials.gov

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