Hypotension resulted from neuraxial block is a common problem, of which is a special issue in patients undergoing Cesarean section. A large number of studies and clinical guidelines suggest that fluid loading, pre- or co-anesthesia, is a promising manner in preventing hypotension. However, it is still a controversy because the fact of a relatively increased blood volume in parturients. In addition, although it is effective of fluid management, it's precise relationship between fluid (crystalloid or colloid) volume and the proportion of hypotension in Cesarean patients under neuraxial anesthesia is still unknown. The investigators designed this trial to clarify the accurate relationship between fluid volume in an escalated manner and the occurrence of hypotension analyzed with a non-linear regression, and wanted to present the 50% effective volume (EV50) of fluid including crystalloid and colloid in preventing hypotension in patients undergoing Cesarean section.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
1,000
Ringer's Lactate 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 15 ml/kg is given to patients pre-, co- and post-neuraxial blocks
Six percent hydroxyethyl starch 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 15 ml/kg is given to patients pre-, co- and post-neuraxial blocks
Nanjing Maternity and Child Health Care Hospital
Nanjing, Jiangsu, China
Rate of hypotension
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Recurrence of hypotension after ephedrine or phenylephrine
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Consumption of ephedrine and phenylephrine
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Duration of hypotension
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
Oxygen saturation during hypotension
Time frame: Anesthesia begin (0 min) to 120 min after anesthesia
One-min and 5-min Apgar scores
Time frame: The first and fifth minute after cesarean successful delivery
Low umbilical cord pH (artery < 7.20)
Time frame: At the time of successful delivery (0 min)
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