RATIONALE: Gathering information about genetic and environmental factors may help doctors learn more about a person's risk for developing prostate cancer. PURPOSE: This research project is studying genes, environment, and prostate cancer risk in patients with or without prostate cancer.
OBJECTIVES: * To determine the association between variation in genes involved in ROS detoxification, oxidative stress response, and prostate cancer risk. * To determine the association between fatty acid levels and prostate cancer risk. OUTLINE: Probands undergo blood and saliva sample collection for fatty acid, DNA, and polymorphism analyses. Archived blood and tissue samples from probands who previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study are also analyzed. Medical records of probands are reviewed for demographics, history and course of disease, and clinical laboratory test results. All probands completed the "Genetic Risk Easy Assessment Tool Family History of Cancer" and "Diet History and Environmental Risk Factor" questionnaires at baseline. If a proband previously participated on our Diet and Prostate Cancer Risk study, he was asked to complete the "Changes in Diet, Prescriptions, Supplementals and Herbal Remedies" questionnaire in addition to the "Genetic Risk Easy Assessment Tool Family History of Cancer" questionnaire at baseline for this study. PROJECTED ACCRUAL: A total of 750 participants will be accrued for this study.
Study Type
OBSERVATIONAL
Enrollment
748
saliva samples will be collected from men (probands) who join the study.
we will genotype DNA samples (buccal) from all probands and conduct a traditional case-control analysis
10ml blood specimen will be obtained and processed (on probands locally-consented and/or those who have an appointment at the VA in Portland, Oregon) to allow for analyses of erythrocyte fatty acids and future nutrient and DNA analyses
Veterans Affairs Medical Center - Portland
Portland, Oregon, United States
Association between variation in genes involved in reactive oxygen species detoxification, oxidative stress response, and prostate cancer risk
Using saliva samples, we conducted analysis on probands' oxidative stress pathway genes and whether these were associated with prostate cancer risk.
Time frame: through study completion; 1 day
Association between blood fatty acids and prostate cancer risk
Using blood samples, we conducted analysis on probands' fatty acid level and whether these were associated with prostate cancer risk.
Time frame: through study completion; 1 day
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PSA results, prostate biopsy pathology reports and clinician notes related to the biopsy are reviewed for final data analysis
probands are asked to complete questionnaires on 1) family history of cancer, 2) diet history over the past year, 3) employment environment and risk factors and/or 4) changes to diet, medications since enrollment in originating case control study
pathology reports will be reviewed for probands whose prostate biopsies reveal cancer; these factors will be evaluated for cancer risk factors
prostate biopsy pathology reports will be reviewed for high risk factors