Empirical implantation of the left ventricular lead is the prevailing practice in cardiac resynchronization therapy device implantation. The response rate to the therapy has been uniformly 70% only despite various methods to screen patients before device implantation. This study tested the hypothesis that echocardiography to assess acute resynchronization of the left ventricle during device implantation may improve the response rate to the therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Empirical implantation of the left ventricular lead during cardiac resynchronization therapy device implantation
Echocardiography-guided implantation of the left ventricular lead during cardiac resynchronization therapy device implantation
Princess Margaret Hospital
Hong Kong, China
Clinical response (Improvement in functional class status by at least one NYHA Class or ≥10% increase in 6-minute hall walk distance) to CRT
Time frame: 6 months after device implantation
Echocardiographic response of ≥15% reduction in LVESV
Time frame: 6 months after device implantation
Echocardiographic response of absolute increase of ≥5% in LVEF
Time frame: 6 months after device implantation
Biochemical response with reduction of BNP level≥15%
Time frame: 6 months after device implantation
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