Intraoperative Bleeding During Endoscopic Sinus Surgery

University of Chicago33 enrolled

Overview

The purpose of this study is to compare the blood loss during sinus surgery looking at two different types of anesthesia: either intravenous anesthesia with propofol or inhalational anesthesia with sevoflurane.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Blood Loss

Interventions

propofolDRUG

100-200mcg/kg/min by infusion

sevofluraneDRUG

1-3% of sevoflurane (expired)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male or female patients who are 18 years of age or older, * ASA grade 1 (normal otherwise healthy patient), * ASA grade 2 (patient with mild systemic disease), * patients who have chronic sinusitis with or without nasal polyps. Exclusion Criteria: * pregnancy, * abnormal coagulation panel * preoperative use of NSAIDS or ASA medications within 7 days, * end-stage renal disease, * allergy to any of the used medications, * maximal body mass index over 35

Locations (1)

The University of Chicago

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Estimated Blood Loss

Estimated blood loss in milliliters per hour is calculated by subtracting the volume of total irrigation used during the case from the total amount of fluid in the suction canister at the end of surgery and dividing by surgical time in hours.

Time frame: from the start of surgery to the end of surgery, up to 6 hours

Secondary Outcomes

Anesthesiologist Numeric Rating Scale (ANRS)

The anesthesiologist numeric rating scale is to rate the ease of the anesthesia technique ranging from 0 to 10 (10 is best, 0 is worst).

Time frame: at the end of surgery (up to 6 hours)

Surgeon's Numeric Rating Scale (SNRS)

The surgeon's numeric rating scale(SNRS)is to rate the surgical conditions (mucosal bleeding and visibility) on a scale ranging from 0 to 10, with 0 defined as cadaveric conditions and 10 as severe bleeding requiring constant suction.

Time frame: at the end of surgery (up to 6 hours)

Data from ClinicalTrials.gov

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