In this double blinded randomized study we evaluate effect of Zinc sulfate for prevention mucositis due to high dose chemotherapy in the patients undergoing bone marrow transplantation whose received Busulfan and/or Cyclophosphamide. Patients randomized in two groups: intervention and control with balanced block randomization method. Intervention group received Zinc sulfate immediately after start conditioning regimen and continued for two weeks. Control group received placebo at the same manner. Prevalence and severity of mucositis will be compared in two groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
Zinc Sulfate: 100 mg of zinc element, per day, bid for two weeks start with chemotherapy
Placebo: as the same of intervention group
Hematology-Oncology & SCT Research Center
Tehran, Tehran Province, Iran
The effect of Zinc Sulfate on prevention of mucositis in patients undergoing bone marrow transplantation
Time frame: 1 year
Evaluation of Zinc Sulfate concentration
Time frame: 1 year
Evaluation of Zinc Sulfate advance effects
Time frame: 1 year
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