The aim of the study is to assess the accuracy of a new paradigm in measuring the level of nociception during lumbar surgery. The paradigm is based the measurement of the baroreflex in response to noxious stimuli in anesthetized patients.
The study aims at exploring the changes in the baroreflex induced by 3 noxious stimulation in anesthetized patients: tracheal intubation, tetanic stimulus, and surgical incision. Patients are randomly assigned to one of 2 groups: remifentanil-2 or remifentanil-4, corresponding to the target effect site concentration of this drug delivered through a TCI system. Other drugs included propofol and cisatracurium. The paradigm exploring the baroreflex collects information continuously recorded of the RR intervals and the changes in systolic arterial pressure, before and during noxious stimuli. The hypothesis is that this paradigm explores nociception as the group with smaller doses in remifentanil will have more cardiovascular reactions in response to noxious stimuli.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
16
anesthesia is induced and maintained with a target-controlled infusion of remifentanil at 2 ng/ml.
anesthesia is induced and maintained with a target-controlled infusion of remifentanil at 4 ng/ml.
University Hospital Grenoble
Grenoble, France
changes in the baroreflex in response to noxious stimuli
Time frame: intraoperative
perioperative requirements in anesthetic agents.
Time frame: intraoperative
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.