Single-arm Study of Photodynamic Laser Therapy Using Foscan for Non-curatively-resectable Bile Duct Carcinoma

Inclusion Criteria: * bile duct carcinoma proven by histology in advanced or non-operable stage or tumor extension: 1. Bismuth type III or IV ( not resectable with R0-margins ) 2. Bismuth type I or II, if resective surgery is contraindicated for old age or poor surgical risk of patient * sufficient general condition to undergo PDT (Karnofsky status \> 30%) * age \> 19 years * access to common bile duct (either via endoscopy after sphincterotomy or percutaneously after transhepatic drainage), * informed written consent Exclusion Criteria: * porphyria or other diseases exacerbated by light * known intolerance or allergies to porphyrin derivatives * a planned surgical procedure within the next 30 days * coexisting ophthalmic disease likely to require slit lamp examination within the next 30 days * impaired kidney or liver function (creatinine \> 2.5x elevated, INR \> 2.2 on vitamin K), * leukopenia ( WBC \< 2000/cmm ) or thrombopenia ( \< 50000/cmm ), * cytotoxic chemotherapy within the past 4 weeks. * pregnancy ( and safe contraception for 6 months after PDT ) * accompanying/complicating disease with very poor prognosis (expected survival \< 6 weeks), * proven advanced peritoneal carcinomatosis ( PET scan imaging, ascites positive for tumor cells)