Preemptive Low-dose Epidural Ketamine for Preventing Chronic Post-thoracotomy Pain

Seoul National University Hospital209 enrolled

Overview

Chronic post-thoracotomy pain is the most common long-term complication that occurs after a thoracotomy with a reported incidence of up to 80%. While thoracic epidural analgesia has become the mainstay for managing acute post-thoracotomy pain, its effect on the chronic post-thoracotomy pain seems questionable. The objective of this prospective, double-blinded, randomized, controlled trial was to assess the effect of preemptive low-dose epidural ketamine in addition to preemptive thoracic epidural analgesia on the incidence of chronic post-thoracotomy pain.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

209

Conditions

Chronic Post-thoracotomy Pain

Interventions

KetamineDRUG

ketamine freeDRUG

Eligibility

Sex: ALLMin age: 19 YearsMax age: 81 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing surgery with a thoracotomy incision Exclusion Criteria: * history of previous thoracic surgery, chronic pain, psychiatric disease, cardiac or vascular disease, neurologic deficits, or contraindications to epidural catheterization such as coagulopathy, or localized or systemic infection

Locations (1)

Seoul National University Hospital

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

Incidence of pain 3 months after surgery

Time frame: 3 months after surgery

Data from ClinicalTrials.gov

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