Several countries in Africa have changed their first-line treatment for uncomplicated malaria to an ACT. Burkina Faso has changed its policy to Artemether-Lumefantrine (AL) and Artesunate-Amodiaquine (AQ+AS). However, such choice has been done without knowing the local effectiveness of these drugs when they are given to patients in real life conditions, without direct observation of the drug administration. Thus, this study aims at investigating the effectiveness of AQ+AS and AL, when given to children with uncomplicated malaria in Burkina Faso.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
340
Coformulated AQ+AS by Sanofi-Aventis has been pre-qualified by WHO in 2008. It is administered once daily for three consecutive days, and it is available in three different dosages (25mg/67.5mg; 50mg/135mg; 100mg/270mg)
Artemether-lumefantrine by Novartis was the first fixed-dose ACT that was prequalified by WHO in April 2004. A 3-day, 6-dose regimen of AL is recommended for infants and children weighing 5-35 kg and adults weighing \> 35 kg.
Nanoro
Nanoro, Boulkiemdé, Burkina Faso
Nanoro
Nanoro, Boulkiemdé, Burkina Faso
IRSS-DRO/Centre Muraz
Bobo-Dioulasso, Bp 545, Burkina Faso
Tinto Halidou
Bobo-Dioulasso, Houet, Burkina Faso
Polymerase chain reaction (PCR) adjusted treatment failure
Time frame: Day 28
Treatment failure up to day 42 (PCR adjusted and unadjusted)
Time frame: Day 42
Gametocytes (prevalence and density)
Time frame: At day 7, 14, 21, 28, 35 and 42 days after treatment
Hb changes
Time frame: Day 35
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