The primary objectives of this clinical trial are to determine if replacing sugar sweetened beverages with water consumption promote weight loss over 6 months in overweight adults and if replacing sugar sweetened beverages with water consumption promote greater weight loss over 6 months relative to replacement with other non-caloric sweetened beverages or control. The secondary objective is to identify mediators and moderators of the effect of water replacement including hydration status, glucose metabolism, anthropometrics, physical activity, dietary intake and resting metabolic rate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
318
Substitution of calorie-dense item with lower calorie choice A
Substitution of calorie-dense item with lower calorie option B
Multiple healthy choices presented with self-selection of choices used
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Weight change
Time frame: 0, 3, 6 months
urine specific gravity
Time frame: 0, 3, 6 months
fasting glucose
Time frame: 0, 3, 6 months
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