Quantitative MR Biomarkers for Sarcoma Treatment

University of Michigan11 enrolled

Overview

To determine if MRI imaging can be used to accurately determine if a sarcoma is responding to the type of chemotherapy being used.

The purpose of this study is to determine if MRI imaging can be used to accurately determine if a sarcoma is responding to the type of chemotherapy being used or if it is ineffective early on in the treatment; instead of finding this out 2-3 months later. If it is determined that MRI can accurately diagnose tumor response, medications can be switched early on potentially improv8ing the patients'chances of recovery.

Study Type

INTERVENTIONAL

Allocation

Masking

NONE

Enrollment

Conditions

Soft Tissue Tumors

Interventions

MRI Scan of soft tissue tumorPROCEDURE

MRI scan will be completed at baseline (prior to start of subject's clinically ordered chemotherapy treatments.

Eligibility

Sex: ALLMin age: 3 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Biopsy proven primary bone or soft tissue tumor 2. No previous treatment for this malignancy 3. Will be given chemotherapy before having surgery or radiation on the tumor. 4. Are able to undergo a MRI examination 5. If your tumor measures at least 1/2 inch in length. Exclusion Criteria: 1. Younger than 3 yrs. of age or need general anesthesia(sedation that puts you to sleep) to have a MRI performed. 2. History of Renal Failure 3. Are not able to have a MRI performed for any reason such as you have a pacemaker or other implanted device that may malfunction or move because of the magnetic field inside the MRI room and scanner. 4. Have any history of an allergic reaction to gadolinium based contrast agents (a medication injected in a vein that helps create clearer MRI images. \-

Locations (1)

University of Michigan Health System

Ann Arbor, Michigan, United States

Outcomes

Primary Outcomes

To determine if MRI imaging can accurately determine if a sarcoma (tumor)is responding to the type of chemotherapy being used.

To image and evaluate the size of the soft tissue tumor prior to chemotherapy treatment.

Time frame: Baseline prior to chemo

Secondary Outcomes

MRI Scan

To evaluate the size of the soft tissue tumor after start of chemotherapy to determine if the chemo is having any notable effect on tumor prior to surgery.

Time frame: 3 weeks post start of chemo and end of chemo

Data from ClinicalTrials.gov

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