The purpose of this study is to determine if the 2 gram single dose of metronidazole is as effective as the 7 day 500 mg BID dose for treatment of Trichomonas vaginalis (TV) among HIV-infected women.
This is a Phase IV equivalency trial as both doses of metronidazole are listed in the the Centers for Disease Control and Prevention Treatment Guidelines for the treatment of T vaginalis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
270
2 gm single dose versus 7 day 500 mg BID dose
HIV Outpatient Clinic
New Orleans, Louisiana, United States
NOAIDS
New Orleans, Louisiana, United States
Crossroads Clinic
Jackson, Mississippi, United States
Thomas St Clinic
Houston, Texas, United States
TV Culture Positive Result
At the participants' test of cure (TOC) visits they were screened for Trichomonas vaginalis using (InPouch) culture. Presence of parasite will yield a culture positive result.
Time frame: test-of-cure visit at 6-12 days post-treatment completion
TV Culture Positive Result
Participants who returned for their follow up visits were tested for Trichomonas vaginalis using InPouch culture. If parasites are present, it will yield a culture positive result.
Time frame: 3 months post-enrollment
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Northwest Clinic
Houston, Texas, United States