Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkina Faso

Inclusion Criteria: * Provision of informed consent before any protocol procedures are performed. * Males and non-pregnant, non-lactating females between the ages of 18 and 45 years, inclusive. * Females and males must agree to practice adequate contraception until at least 28 days following their last immunization dose (including abstinence; hormonal contraception; condoms with spermicidal agents; post-menopausal; or surgical sterilization/vasectomy). * Participants must agree to avoid high risk sexual behavior for exposure to human immunodeficiency virus (HIV). * In good health as determined by screening medical history, physical examination (PE), and laboratory assessments. * Willingness to comply with protocol requirements. * Willingness to be contacted for one year for assessment of serious adverse events. * Must be a permanent resident of the Saponé health district (villages around Balonghin) in Burkina Faso. Exclusion Criteria: * Current or recent (within the last four weeks) treatment with parenteral, inhaled, or oral corticosteroids (intranasal steroids are acceptable), or other immunosuppressive agents, or chemotherapy. * History of splenectomy. * Abnormal screening laboratory values. Any abnormal screening value for any screening test will exclude the subject from the study. Abnormal screening labs will not be repeated with the exception of high glucose levels will be repeated at a fasting state. * History of intravenous (IV) drug abuse. * History of, or current medical, occupational, social or family problems as a result of alcohol or illicit drug use. * History of moderate to severe mental illness, as defined by symptoms interfering with social or occupational function or suicidal thoughts/attempts. * History of receiving blood or blood products (such as blood transfusion, platelet transfusion, immunoglobulins, hyperimmune serum) in the previous 6 months. * Vaccination with a live vaccine within the past 30 days or with a nonreplicating, inactivated, or subunit vaccine within the last 14 days. * Known hypersensitivity to components of the vaccine. * History of acute or chronic medical conditions including, but not limited to, disorders of the liver, kidney, lung, heart, or nervous system, or other metabolic or autoimmune/inflammatory conditions. * History of coagulation defect or bleeding from (bruising at) multiple sites that cannot be linked to trauma or surgery. * History of anaphylaxis or severe hypersensitivity reaction. * Severe asthma, as defined by an emergency room visit or hospitalization within the last 12 months. * Pregnant or breastfeeding women. * Acute illness, including temperature \>37.8 degrees Celsius within one week prior to vaccination. * Positive serology for human immunodeficiency virus (HIV), hepatitis C virus (HCV), or hepatitis B surface antigen (HBsAg). * Concurrent participation in other investigational protocols or receipt of an investigational product within the previous 30 days or planned receipt of an investigational product within 28 days following the last immunization dose. * Identification of any condition that, in the opinion of the investigator, would affect the ability of the subject to understand or comply with the study protocol or would jeopardize the safety or rights of a subject participating in the study. * History of malignancy, including hematologic and skin cancers (except for a localized basal cell carcinoma), or known immunodeficiency syndrome. * History of previous receipt of a malaria vaccine. * Pre-medication with analgesic or antipyretic agents in the 6 hours prior to vaccination, or planned medication with analgesic or antipyretic in the 24 hours following vaccination. This criterion should not preclude subjects receiving such medication if the need arises. * Receipt of a recombinant adenovirus vector vaccine in a prior study.