The purpose of this study is to determine if Vitamin D supplementation helps prevent recurrent cardiovascular events, such as heart attack or stroke, in patients who have already experienced at least one cardiovascular event. This study will investigate if the addition of 150,000 international units of cholecalciferol (vitamin D3) by mouth every 2 months to a subject's medication regimen will prevent further cardiovascular events.
The purpose of this study is to determine if Vitamin D supplementation helps prevent recurrent cardiovascular events, such as heart attack or stroke, in patients who have already experienced at least one cardiovascular event. This study will investigate if the addition of 150,000 international units of cholecalciferol (vitamin D3) by mouth every 2 months to a subject's medication regimen will prevent further cardiovascular events.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
24
cholecalciferol 150,000 IU by mouth every 2 months for 1 year
placebo by mouth every 2 months for 1 year
The Cardiac Center at Creighton University
Omaha, Nebraska, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
To give oral vitamin D supplements and raise the blood levels of 25-OH D in the study subjects to >30ng/ml.
Time frame: 1 year
To see if raising the serum 25(OH) D levels reduces the incidence of cardiovascular events in patients with coronary artery disease (CAD).
Time frame: 1 year
To see if higher serum 25(OH) D levels will help in better control of blood pressure.
Time frame: 1 year
To perform proteomics analysis to: a) Extract total protein; b) Profile protein expression in 2-DE and /or 2-DLC and direct mass spectrometric analysis (dMS) on the serum of vitamin D supplemented and placebo subjects.
Time frame: 1 year
To compare protein expression profiles and/or MS spectrum pattern recognition, and identify differentially expressed proteins in vitamin D supplemented and placebo subjects.
Time frame: 1 year
To obtain bone mineral density measurements (by DXA) and assess bone markers in subjects with known coronary artery disease
Time frame: 1 year
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