Role of Indoor Pollutants on House Dust Mite Allergic Asthma

N/AWithdrawnNCT01019291

University Hospital, Strasbourg, France

Overview

It seems that the aldehydes and NO2, at the levels found indoor, could be the aggravating factors for an allergic response. However this effect has not been demonstrated. The investigators plan to study the effect of exposure to standard doses of these pollutants on the bronchial reactivity as measured by bronchial challenge tests with dust mite extract in volunteers asthmatic, allergic to house dust mite.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Conditions

Allergic Asthma Allergy to House Dust Mite

Interventions

Formaldehyde and NO2 (Exposure to indoor pollutants)OTHER

Exposure to indoor pollutants (Formaldehyde and NO2) in a randomized way, followed by bronchial challenge test with house dust mite extract.

Placebo (Exposure to indoor pollutants)OTHER

Exposure to indoor pollutants (placebo) in a randomized way, followed by bronchial challenge test with house dust mite extract.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion criteria: * M/F 18-50 years of age * History of intermittent HDM allergic asthma-FEV1 \> 80% * Non smokers or smokers with smoking \< 10 PY Exclusion criteria: * Persistent asthma and FEV1\<80% * Allergic to pets and pets at home

Locations (1)

Unité de Pneumologie, d'Allergologie et de Pathologie Respiratoire de l'Environnement, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Data from ClinicalTrials.gov

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