The purpose of this study was to provide stronger evidence for extended-dose chloroquine treatment of falciparum-positive Afghan refugees in Northwest Frontier Province (NWFP), Pakistan or justification for discontinuation of the policy.
To determine whether extended-dose chloroquine provided better cure rates and fewer recrudescences than standard chloroquine treatment among Afghan refugees, 163 falciparum patients from three Afghan refugee camps were recruited into 3-day (CQ 25mg/kg) or 5-day (CQ 40mg/kg) treatment arms and followed for up to 60 days.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
163
Comparison of two different dosages of chloroquine for treatment of falciparum malaria in Afghan refugee camps in Northwest Frontier Province, Pakistan
Adezai Basic Health Unit
Adezai, Khyber Pakhtunkhwa, Pakistan
Baghicha Basic Health Unit
Bāghīcha, Khyber Pakhtunkhwa, Pakistan
Kagan Basic Health Unit
Kagan, Khyber Pakhtunkhwa, Pakistan
therapeutic and parasitological cure with no recrudescence
Time frame: 60 days
parasite clearance time
Time frame: 28 days
fever clearance time
Time frame: 28 days
gametocytaemia
Time frame: 28 days
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