Deep Anterior Lamellar Keratoplasty (DALK) Using Acellular Corneal Tissue Promotes Corneal Allograft Survival in High Risk Patients

Wenzhou Medical University78 enrolled

Overview

The purpose of this study is to study whether deep anterior lamellar keratoplasty (DALK) using acellular tissue will promote corneal graft survival in high risk patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Glycerin Cryopreserved Acellular Corneal Tissue Deep Anterior Lamellar Keratoplasty High Risk Keratoplasty

Interventions

DALK using GCCTPROCEDURE

Deep anterior lamellar keratoplasty (DALK) using glycerin-cryopreserved corneal tissue

DALK using FCTPROCEDURE

Deep anterior lamellar keratoplasty (DALK) using fresh corneal tissue

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * severe bacterial keratitis * Herpes simplex keratitis * severe fungal keratitis * partial limbal deficiency after chemical burn Exclusion Criteria: * posterior stroma involved in severe bacterial and fungal keratitis * dry eye * glaucoma or intraocular pressure greater than 21 mmHg * amblyopia * retinal abnormalities * patients with severe systemic diseases not good for ocular surgery

Locations (1)

Eye Hospital, Wenzhou Medical College

Wenzhou, Zhejiang, China

Outcomes

Primary Outcomes

rejection

Secondary Outcomes

laser scanning in vivo confocal microscopy

Data from ClinicalTrials.gov

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